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Imaging white matter dysfunction in major psychiatric disorders

Using resting-state functional MRI, we revealed a dysfunction pattern in the white matter of people with four major psychiatric disorders. This pattern is distinct from structural changes and has specific molecular and genetic bases.

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Fig. 1: Dysfunctional WM tracts in major psychiatric disorders.


  1. Koshiyam, D. et al. White matter microstructural alterations across four major psychiatric disorders: mega-analysis study in 2937 individuals. Mol. Psychiatry 25, 883–895 (2020). This paper shows the common microstructural changes of WM across psychiatric disorders.

    Article  Google Scholar 

  2. Ji, G. J. et al. Low-frequency blood oxygen level-dependent fluctuations in the brain white matter: more than just noise. Sci. Bull. 62, 656–657 (2017). This paper shows the importance of functional MRI signals in WM.

    Article  Google Scholar 

  3. Goodkind, M. et al. Identification of a common neurobiological substrate for mental illness. JAMA Psychiatry 72, 305–315 (2015). This paper shows the common network of different psychiatric disorders.

    Article  PubMed  PubMed Central  Google Scholar 

  4. Boes, A. D. et al. Network localization of neurological symptoms from focal brain lesions. Brain 138, 3061–3075 (2015). This paper introduces the lesion network mapping method.

    Article  PubMed  PubMed Central  Google Scholar 

  5. Ji, G. J. et al. Regional and network properties of white matter function in Parkinson’s disease. Hum. Brain Mapp. 40, 1253–1263 (2019). This paper reports WM dysfunction in Parkinson’s disease.

    Article  PubMed  Google Scholar 

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This is a summary of: Ji, G.-J. et al. White matter dysfunction in psychiatric disorders is associated with neurotransmitter and genetic profiles. Nat. Ment. Health (2023).

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Imaging white matter dysfunction in major psychiatric disorders. Nat. Mental Health 1, 613–614 (2023).

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