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Time to synergize mental health with brain health

This Comment highlights the intertwined nature of mental and brain health and disease. Common genetic, environmental and lifestyle factors contribute to psychiatric and neurological disorders, which partially share neurocognitive and pathophysiological mechanisms. A call for a more dimensional, interdisciplinary approach can accelerate the development of robust approaches to research, prevention and intervention.

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Fig. 1: Common and interconnected levels of analysis across mental health and brain health fields and diseases.


  1. Ibanez, A. et al. World Psychiatry 13, 148–149 (2014).

    Article  PubMed  PubMed Central  Google Scholar 

  2. Thibaut, F. Dialogues Clin. Neurosci. 20, 251–252 (2018).

    Article  PubMed  PubMed Central  Google Scholar 

  3. Tian, Y. E. et al. JAMA Psychiatry 80, 567–576 (2023).

    Article  PubMed  Google Scholar 

  4. Craske, M. G. et al. Nat. Ment. Health 1, 12–24 (2023).

    Article  Google Scholar 

  5. Avan, A. & Hachinski, V. Alzheimers Dement. 18, 1396–1407 (2022).

    Article  PubMed  Google Scholar 

  6. Leffa, D. T. et al. Mol. Psychiatry 28, 1248–1255 (2023).

    Article  PubMed  Google Scholar 

  7. Qureshi, I. A. & Mehler, M. F. Handb. Clin. Neurol. 147, 43–58 (2018).

    Article  PubMed  PubMed Central  Google Scholar 

  8. Vermeulen, R. et al. Science 367, 392–396 (2020).

    Article  PubMed  PubMed Central  Google Scholar 

  9. Hsiao, Y. H. et al. J. Sleep Res. 26, 623–628 (2017).

    Article  PubMed  Google Scholar 

  10. Ibanez, A. et al. Soc. Neurosci. 13, 1–39 (2018).

    Article  PubMed  Google Scholar 

  11. Ibanez, A. Trends Cogn. Sci. 26, 1031–1034 (2022).

    Article  PubMed  Google Scholar 

  12. Migeot, J. A. et al. Trends Neurosci. 45, 838–853 (2022).

    Article  PubMed  Google Scholar 

  13. Khansari, P. S. & Sperlagh, B. Inflammopharmacology 20, 103–107 (2012).

    Article  PubMed  Google Scholar 

  14. Luppi, A. I. et al. Nat. Rev. Neurosci. 23, 767–768 (2022).

    Article  PubMed  Google Scholar 

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This work was supported by grants from Takeda CW2680521; ANID/FONDECYT Regular (1210195, 1210176 and 1220995); ANID/FONDAP/15150012; and ReDLat: the National Institutes of Health and the Fogarty International Center (FIC), National Institutes of Aging (R01 AG057234), Alzheimer’s Association (SG-20-725707), Rainwater Charitable Foundation; and Global Brain Health Institute (all grants to A.I.). The contents of this publication are solely the authors’ responsibility and do not represent the official views of these institutions.

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Correspondence to Agustin Ibanez.

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Nature Mental Health thanks Joëlle Rüegg and the other, anonymous, reviewer(s) for their contribution to the peer review of this work.

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Ibanez, A., Zimmer, E.R. Time to synergize mental health with brain health. Nat. Mental Health 1, 441–443 (2023).

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