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Evolution of cardiac genomic elements in humans and non-human primates

Analyses of transcription and translation identify newly evolved genes and translated sequences (open reading frames) unique to hearts from human and non-human primates, suggesting that these genetic innovations might influence cardiac development and disease.

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Fig. 1: New evolutionary innovations in human and NHP heart genomes.

References

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This is a summary of: Ruiz-Orera, J. et al. Evolutions of translational control and the emergence of genes and open reading frames in human and non-human primate hearts. Nat. Cardiovasc. Res. https://doi.org/10.1038/s44161-024-00544-7 (2024).

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Evolution of cardiac genomic elements in humans and non-human primates. Nat Cardiovasc Res (2024). https://doi.org/10.1038/s44161-024-00552-7

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