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Cardiac regeneration

Success in heart regeneration depends on endocardial innate immune signaling

Nature Cardiovascular Research volume 3, pages 1031–1032 (2024)Cite this article

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The endocardium is activated immediately after injury and promotes cardiac muscle regeneration by producing growth factors. Research now shows that innate immune signaling is crucial for the regenerative function of the endocardium.

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Fig. 1: Endocardial MyD88 signaling regulates cardiac regeneration in zebrafish.

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Authors and Affiliations

  1. Department of Cardiac Regeneration Biology, National Cerebral and Cardiovascular Center Research Institute, Suita, Japan

    Kazu Kikuchi

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  1. Kazu Kikuchi
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Correspondence to Kazu Kikuchi.

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The author has no conflicts of interest directly relevant to the content of this article.

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Kikuchi, K. Success in heart regeneration depends on endocardial innate immune signaling. Nat Cardiovasc Res 3, 1031–1032 (2024). https://doi.org/10.1038/s44161-024-00539-4

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