Endothelial-cell-specific inactivation of Lats2 or overexpression of YAP1, which are components of the Hippo pathway, induces myofibroblast formation. This leads to extensive fibrosis, osteosclerosis and impaired bone marrow function, and such changes are mediated by endothelial-to-mesenchymal transition. These findings offer insights into potential therapeutic strategies for myelofibrosis and osteosclerosis.
This is a preview of subscription content, access via your institution
Access options
Subscribe to this journal
Receive 12 digital issues and online access to articles
$119.00 per year
only $9.92 per issue
Buy this article
- Purchase on SpringerLink
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
References
Erba, B. G. et al. Endothelial-to-mesenchymal transition in bone marrow and spleen of primary myelofibrosis. Am. J. Pathol. 187, 1879–1892 (2017). This report provides evidence for EndMT in people with primary myelofibrosis and in a mouse model of the disease.
Ghosh, K., Shome, D. K., Kulkarni, B., Ghosh, M. K. & Ghosh, K. Fibrosis and bone marrow: understanding causation and pathobiology. J. Transl. Med. 21, 697–718 (2023). A review article that discusses many fundamental aspects of bone marrow fibrosis.
Kramann, R. & Schneider, R. K. The identification of fibrosis-driving myofibroblast precursors reveals new therapeutic avenues in myelofibrosis. Blood 131, 2111–2119 (2018). A review article focusing on the emergence of myofibroblasts during myelofibrosis.
Piccolo, S., Dupont, S. & Cordenonsi, M. The biology of YAP/TAZ: hippo signaling and beyond. Physiol. Rev. 94, 783–803 (2014). A review article that summarizes the function and regulation of the Hippo pathway.
Additional information
Publisher’s note Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.
This is a summary of: Sivaraj, K. K. et al. Endothelial LATS2 is a suppressor of bone marrow fibrosis. Nat. Cardiovasc. Res. https://doi.org/10.1038/s44161-024-00508-x (2024).
Rights and permissions
About this article
Cite this article
Endothelial cells modulate bone marrow fibrosis. Nat Cardiovasc Res 3, 895–896 (2024). https://doi.org/10.1038/s44161-024-00521-0
Published:
Issue Date:
DOI: https://doi.org/10.1038/s44161-024-00521-0
