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Endothelial biology

Loss of fenestrae in liver sinusoidal endothelial cells contributes to MASLD

Liver sinusoidal endothelial cells have small pores called fenestrae that allow bidirectional exchange of substrates such as lipids between hepatocytes and blood. New work reveals molecular pathways linking hyperlipidemia to these cells’ loss of fenestrae as a starting point for metabolic dysfunction-associated steatotic liver disease.

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Fig. 1: Underlying mechanisms of LSEC capillarization in MASLD.

References

  1. Raggi, P. et al. Atherosclerosis 392, 117523 (2024).

    Article  CAS  PubMed  Google Scholar 

  2. Poisson, J. et al. J. Hepatol. 66, 212–227 (2017).

    Article  CAS  PubMed  Google Scholar 

  3. Hammoutene, A. & Rautou, P.-E. J. Hepatol. 70, 1278–1291 (2019).

    Article  CAS  PubMed  Google Scholar 

  4. Rautou, P. E. et al. Hepatology 74, abstr. 1874 (2021).

  5. Kawashita, E., Ozaki, T., Ishihara, K., Kashiwada, C. & Akiba, S. Life Sci. 294, 120355 (2022).

    Article  CAS  PubMed  Google Scholar 

  6. Guo, Q. et al. Front. Immunol. 13, 983255 (2022).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  7. Szafranska, K., Kruse, L. D., Holte, C. F., McCourt, P. & Zapotoczny, B. Front. Physiol. 12, 735573 (2021).

    Article  PubMed  PubMed Central  Google Scholar 

  8. Eberhard, D. et al. Nat. Cardiovasc. Res. https://doi.org/10.1038/s44161-024-00487-z (2024).

    Article  Google Scholar 

  9. Alto, L. T. & Terman, J. R. Methods Mol. Biol. 1493, 1–25 (2017).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  10. Manicardi, N. et al. Cancers 3, 2688 (2021).

    Article  Google Scholar 

  11. Šamadan, L. et al. Biomedicines 10, 3014 (2022).

    Article  PubMed  PubMed Central  Google Scholar 

  12. Zhou, J. et al. Minerva Endocrinol 48, 194–205 (2023).

    Article  Google Scholar 

  13. Pan, Q. Cancer Cell 11, 53–67 (2007).

    Article  CAS  PubMed  Google Scholar 

  14. Gracia-Sancho, J., Caparrós, E., Fernández-Iglesias, A. & Francés, R. Nat. Rev. Gastroenterol. Hepatol. 18, 411–431 (2021).

    Article  PubMed  Google Scholar 

  15. Maeso-Díaz, R. et al. Aging Cell 17, e12829 (2018).

    Article  PubMed  PubMed Central  Google Scholar 

Download references

Acknowledgements

P-E.R.’s research laboratory is supported by the Fondation pour la Recherche Médicale (FRM EQU202303016287), the Institut National de la Santé et de la Recherche Médicale (ATIP AVENIR), the Agence Nationale pour la Recherche (ANR-18-CE14-0006-01, RHU QUID-NASH, ANR-18-IDEX-0001 and ANR-22-CE14-0002), Émergence - Ville de Paris, the Fondation ARC, the European Union’s Horizon 2020 research and innovation program under grant agreement no. 847949 and by France 2030 RHU LIVER-TRACK.

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Correspondence to Johanne Poisson.

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P.-E.R. has received research funding from Terrafirma and acted as consultant for Hemostod, Mursla, Genfit, Boehringer Ingelheim and Abbelight and received speaker fees from Tillots Pharma and AbbVie. All other authors have no competing interests.

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Ciriaci, N., Rautou, PE. & Poisson, J. Loss of fenestrae in liver sinusoidal endothelial cells contributes to MASLD. Nat Cardiovasc Res 3, 622–624 (2024). https://doi.org/10.1038/s44161-024-00490-4

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