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Macrophages behave like mural cells to promote healing of ischemic muscle injury

We discover a function of innate immune cells that is important for healing injury: macrophages adopt mural cell roles that are important for restoring blood vessel function and perfusion.

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Fig. 1: Macrophages acquire a mural cell-like phenotype that is essential for the restoration of blood perfusion at sites of ischemic injury.


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This is a summary of: Amoedo-Leite, C. et al. Macrophages upregulate mural cell-like markers and support healing of ischemic injury by adopting functions important for vascular support. Nat. Cardiovasc. Res. (2024).

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Macrophages behave like mural cells to promote healing of ischemic muscle injury. Nat Cardiovasc Res 3, 625–626 (2024).

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