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Neutrophil extracellular traps trigger IgA loss after stroke and myocardial infarction

The mechanisms by which stroke and myocardial infarction trigger lymphocyte loss remain poorly defined. This study shows that the release of neutrophil extracellular traps (NETs) after stroke and myocardial infarction triggers B cell apoptosis and reduces the number of IgA-producing plasma cells. Therapeutic targeting of NETs is immunoprotective in mice and humans.

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Fig. 1: NETs released after ischemic stroke induce B cell loss and reduce plasma levels of IgA.


  1. Westendorp, W. F., Dames, C., Nederkoorn, P. J. & Meisel, A. Immunodepression, infections, and functional outcome in ischemic stroke. Stroke 53, 1438–1448 (2022). A review article on post-stroke immunodeficiency and systemic infections.

    Article  CAS  PubMed  Google Scholar 

  2. Stanley, D. et al. Translocation and dissemination of commensal bacteria in post-stroke infection. Nat. Med. 22, 1277–1284 (2016). This paper reports intestinal bacteria invasion to systemic tissues after ischemic stroke.

    Article  CAS  PubMed  Google Scholar 

  3. Roth, S. et al. Post-injury immunosuppression and secondary infections are caused by an AIM2 inflammasome-driven signaling cascade. Immunity 54, 648–659.e648 (2021). This paper describes the apoptosis of splenic T cells after ischemic stroke.

    Article  CAS  PubMed  Google Scholar 

  4. Reboldi, A. et al. IgA production requires B cell interaction with subepithelial dendritic cells in Peyer’s patches. Science 352, aaf4822 (2016). This paper defines B cell interactions for IgA synthesis in Peyer’s patches.

    Article  PubMed  PubMed Central  Google Scholar 

  5. Silva, C. M. S. et al. Gasdermin D inhibition prevents multiple organ dysfunction during sepsis by blocking NET formation. Blood 138, 2702–2713 (2021). This paper reports that inhibition of NET formation by gasdermin D blockage reduces sepsis.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

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This is a summary of: Tuz, A. A. et al. Stroke and myocardial infarction induce neutrophil extracellular trap release disrupting lymphoid organ structure and immunoglobulin secretion. Nat. Cardiovasc. Res. (2024).

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Neutrophil extracellular traps trigger IgA loss after stroke and myocardial infarction. Nat Cardiovasc Res 3, 496–497 (2024).

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