Hepatocytes are recognized as having a primary role in production and clearance of apolipoprotein B100-containing lipoproteins. A new study finds that Kupffer cells can respond to the initial atherogenic dyslipidemia and regulate levels of circulating lipoprotein.
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References
VanderLaan, P. A., Reardon, C. A., Thisted, R. A. & Getz, G. S. J. Lipid Res. 50, 376–385 (2009).
Heeren, J. & Scheja, L. Mol. Metab. 50, 101238 (2021).
Di Nunzio, G., Hellberg, S. & Malin, S. G. Nat. Cardiovasc. Res. https://doi.org/10.1038/s44161-024-00448-6 (2024).
Zoppini, G. et al. Medicine 95, e4821 (2016).
Tabas, I., Garcia-Cardena, G. & Owens, G. K. J. Cell Biol. 209, 13–22 (2015).
Ioannou, G. N. Trends Endocrinol. Metab. 27, 84–95 (2016).
Van Rooijen, N. & Sanders, A. Hepatology 23, 1239–1243 (1996).
Breuer, D. A. et al. Am. J. Physiol. Gastrointest. Liver Physiol. 318, G211–G224 (2020).
Finney, A. C. et al. Front. Cardiovasc. Med. 10, 1116861 (2023).
Kamps, J. A., Kruijt, J. K., Kuiper, J. & Van Berkel, T. J. Biochem. J. 276, 135–140 (1991).
Mallat, Z. et al. Circ. Res. 89, E41–E45 (2001).
Arai, S. et al. Cell Metab. 1, 201–213 (2005).
Zhao, L. et al. J. Gastroenterol. Hepatol. 26, 875–883 (2011).
Guedeney, P. et al. Eur. Heart J. 43, e17–e25 (2022).
Baragetti, A. et al. Eur. J. Prev. Cardiol. 24, 1870–1877 (2017).
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Ma, F., Huang, X. & Cai, B. Linking MASLD to ACVD through Kupffer cells. Nat Cardiovasc Res 3, 258–259 (2024). https://doi.org/10.1038/s44161-024-00442-y
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DOI: https://doi.org/10.1038/s44161-024-00442-y