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Kupffer cells

Linking MASLD to ACVD through Kupffer cells

Hepatocytes are recognized as having a primary role in production and clearance of apolipoprotein B100-containing lipoproteins. A new study finds that Kupffer cells can respond to the initial atherogenic dyslipidemia and regulate levels of circulating lipoprotein.

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Fig. 1: The role of liver-mediated lipoprotein metabolism in atherosclerosis.

References

  1. VanderLaan, P. A., Reardon, C. A., Thisted, R. A. & Getz, G. S. J. Lipid Res. 50, 376–385 (2009).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  2. Heeren, J. & Scheja, L. Mol. Metab. 50, 101238 (2021).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  3. Di Nunzio, G., Hellberg, S. & Malin, S. G. Nat. Cardiovasc. Res. https://doi.org/10.1038/s44161-024-00448-6 (2024).

    Article  Google Scholar 

  4. Zoppini, G. et al. Medicine 95, e4821 (2016).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  5. Tabas, I., Garcia-Cardena, G. & Owens, G. K. J. Cell Biol. 209, 13–22 (2015).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  6. Ioannou, G. N. Trends Endocrinol. Metab. 27, 84–95 (2016).

    Article  CAS  PubMed  Google Scholar 

  7. Van Rooijen, N. & Sanders, A. Hepatology 23, 1239–1243 (1996).

    Article  PubMed  Google Scholar 

  8. Breuer, D. A. et al. Am. J. Physiol. Gastrointest. Liver Physiol. 318, G211–G224 (2020).

    Article  CAS  PubMed  Google Scholar 

  9. Finney, A. C. et al. Front. Cardiovasc. Med. 10, 1116861 (2023).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  10. Kamps, J. A., Kruijt, J. K., Kuiper, J. & Van Berkel, T. J. Biochem. J. 276, 135–140 (1991).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  11. Mallat, Z. et al. Circ. Res. 89, E41–E45 (2001).

    CAS  PubMed  Google Scholar 

  12. Arai, S. et al. Cell Metab. 1, 201–213 (2005).

    Article  CAS  PubMed  Google Scholar 

  13. Zhao, L. et al. J. Gastroenterol. Hepatol. 26, 875–883 (2011).

    Article  CAS  PubMed  Google Scholar 

  14. Guedeney, P. et al. Eur. Heart J. 43, e17–e25 (2022).

    Article  CAS  PubMed  Google Scholar 

  15. Baragetti, A. et al. Eur. J. Prev. Cardiol. 24, 1870–1877 (2017).

    Article  PubMed  Google Scholar 

Download references

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Correspondence to Bishuang Cai.

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Ma, F., Huang, X. & Cai, B. Linking MASLD to ACVD through Kupffer cells. Nat Cardiovasc Res 3, 258–259 (2024). https://doi.org/10.1038/s44161-024-00442-y

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