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Metabolism and epigenetics

Propionyl-CoA metabolism links chromatin acylation to cardiac transcription

The molecular mechanisms that link propionyl-CoA metabolism and epigenetic regulation of gene expression are unclear, as are the implications for heart function. Now, new insights into the modulation of chromatin acylation and transcription by aberrant oxidation of propionyl-CoA are revealed in the dysfunctional hearts of mice with propionic acidemia.

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Fig. 1: A role for pr-CoA in cardiac transcription and health.

References

  1. Kitamura, N. & Galligan, J. J. Biochem J 480, 1241–1265 (2023).

    Article  CAS  PubMed  Google Scholar 

  2. Trefely, S., Lovell, C. D., Snyder, N. W. & Wellen, K. E. Mol. Metab. 38, 100941 (2020).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  3. Park, K. et al. Nat. Cardiovasc. Res. https://doi.org/10.1038/s44161-023-00365-0 (2023).

    Article  Google Scholar 

  4. Reszko, A. E. et al. J. Biol. Chem. 278, 34959–34965 (2003).

    Article  CAS  PubMed  Google Scholar 

  5. Kebede, A. F. et al. Nat. Struct. Mol. Biol. 24, 1048–1056 (2017).

    Article  CAS  PubMed  Google Scholar 

  6. Trefely, S. et al. Mol. Cell 82, 447–462.e6 (2022).

    Article  CAS  PubMed  Google Scholar 

  7. Waldecker, M., Kautenburger, T., Daumann, H., Busch, C. & Schrenk, D. J. Nutr. Biochem. 19, 587–593 (2008).

    Article  CAS  PubMed  Google Scholar 

  8. Wikoff, W. R., Gangoiti, J. A., Barshop, B. A. & Siuzdak, G. Clin. Chem. 53, 2169–2176 (2007).

    Article  CAS  PubMed  Google Scholar 

  9. Park, K. C., Krywawych, S., Richard, E., Desviat, L. R. & Swietach, P. Front. Cardiovasc. Med. 7, 617451 (2020).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  10. Ning, K., Fermin, D. & Nesvizhskii, A. I. J. Proteome Res. 11, 2261–2271 (2012).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  11. Yang, Z., He, M., Austin, J., Sayed, D. & Abdellatif, M. J. Clin. Invest. https://doi.org/10.1172/JCI169399 (2023).

    Article  PubMed  PubMed Central  Google Scholar 

Download references

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Correspondence to Christina Demetriadou, Andrew A. Gibb, John W. Elrod or Nathaniel W. Snyder.

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Demetriadou, C., Gibb, A.A., Elrod, J.W. et al. Propionyl-CoA metabolism links chromatin acylation to cardiac transcription. Nat Cardiovasc Res 2, 1109–1111 (2023). https://doi.org/10.1038/s44161-023-00381-0

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