Effective pharmacological treatment options for abdominal aortic aneurysm (AAA) are missing. A study by Zhang et al. suggests that targeting the thrombo-inflammatory activity of platelets by blocking the intracellular accumulation of ceramides might limit AAA progression while not affecting hemostatic platelet function.
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Golledge, J. Nat. Rev. Cardiol. 16, 225–242 (2019).
Cameron, S. J. et al. Blood 132, 2619–2628 (2018).
Owens, A. P. et al. Arterioscler. Thromb. Vasc. Biol. 35, 2032–2041 (2015).
Lindholt, J. S. et al. Vasc. Endovascular. Surg. 42, 329–334 (2008).
Thompson, A. et al. J. Vasc. Surg. 52, 55–61 (2010).
Stoll, G. & Nieswandt, B. Nat. Rev. Neurol. 15, 473–481 (2019).
Kleinschnitz, C. et al. Circulation 115, 2323–2330 (2007).
Nieswandt, B. et al. J. Physiol. 589, 4115–4123 (2011).
Zhang, X. et al. Nat. Cardiovasc. Res. https://doi.org/10.1038/s44161-023-00364-1 (2023).
Choi, R. H. et al. Nat. Rev. Cardiol. 18, 701–711 (2021).
We thank V. Göb and S. Beck for critical reading of the manuscript, and S. Beck for help with preparation of the figure. The work in our laboratory is continuously funded by the Deutsche Forschungsgemeinschaft (DFG; German Research Foundation), project number 374031971–TRR 240 and project number 453989101–SFB1525.
The authors declare no competing interests.
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Nieswandt, B., Vögtle, T. Platelet ceramides drive thrombo-inflammation in aortic aneurysm formation. Nat Cardiovasc Res 2, 1112–1114 (2023). https://doi.org/10.1038/s44161-023-00374-z