Structural determination of the ABCC4 transporter is a major first step in providing crucial molecular insights into the transport of platelet substrates into granules, as well as drug transport from platelets. The findings provide a framework for understanding platelet interactions and potential design of specific platelet antagonists.
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This work was funded by National Institutes of Health (NIH) National Heart, Lung, and Blood Institute (NHLBI) (R01-HL122815, R01-HL150515 and R01-HL115247) to J.H., a K08 award to A.S. (K08-HL150246), and a T32 to S.X.G. (T32-HL007974).
The authors declare no competing interests.
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Sharda, A.V., Gu, S.X. & Hwa, J. Insights into platelet pharmacology from a cryo-EM structure of the ABCC4 transporter. Nat Cardiovasc Res 2, 606–608 (2023). https://doi.org/10.1038/s44161-023-00293-z