Preserving hemostasis while preventing pathological thrombosis has been a central goal in drug development. A new way to restore hemostasis is suggested by the finding that glycoprotein V is cleaved by thrombin on activated platelets, negatively regulating clotting at sites of vascular injury.
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Han, X. & Nieman, M. T. Thromb. Res. 196, 87–98 (2020).
Ravanat, C. et al. Blood 89, 3253–3262 (1997).
Ramakrishnan, V. et al. Proc. Natl Acad. Sci. USA 98, 1823–1828 (2001).
Beck, S. et al. Nat. Cardiovasc. Res. https://doi.org/10.1038/s44161-023-00254-6 (2023).
Ni, H. et al. Blood 98, 368–373 (2001).
De Candia, E. et al. J. Biol. Chem. 276, 4692–4698 (2001).
Adam, F., Verbeuren, T. J., Fauchère, J.-L., Guillin, M.-C. & Jandrot-Perrus, M. J. Thromb. Haemost. 1, 798–804 (2003).
Kamath, P., Huntington, J. A. & Krishnaswamy, S. J. Biol. Chem. 285, 28651–28658 (2010).
The authors have no competing interests.
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Knauss, E.A., Nieman, M.T. Glycoprotein V exerts local control of fibrin. Nat Cardiovasc Res 2, 335–336 (2023). https://doi.org/10.1038/s44161-023-00261-7