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Glycoprotein V exerts local control of fibrin

Preserving hemostasis while preventing pathological thrombosis has been a central goal in drug development. A new way to restore hemostasis is suggested by the finding that glycoprotein V is cleaved by thrombin on activated platelets, negatively regulating clotting at sites of vascular injury.

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  1. Han, X. & Nieman, M. T. Thromb. Res. 196, 87–98 (2020).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  2. Ravanat, C. et al. Blood 89, 3253–3262 (1997).

    Article  CAS  PubMed  Google Scholar 

  3. Ramakrishnan, V. et al. Proc. Natl Acad. Sci. USA 98, 1823–1828 (2001).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  4. Beck, S. et al. Nat. Cardiovasc. Res. (2023).

  5. Ni, H. et al. Blood 98, 368–373 (2001).

    Article  CAS  PubMed  Google Scholar 

  6. De Candia, E. et al. J. Biol. Chem. 276, 4692–4698 (2001).

    Article  PubMed  Google Scholar 

  7. Adam, F., Verbeuren, T. J., Fauchère, J.-L., Guillin, M.-C. & Jandrot-Perrus, M. J. Thromb. Haemost. 1, 798–804 (2003).

    Article  CAS  PubMed  Google Scholar 

  8. Kamath, P., Huntington, J. A. & Krishnaswamy, S. J. Biol. Chem. 285, 28651–28658 (2010).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

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Correspondence to Marvin T. Nieman.

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Knauss, E.A., Nieman, M.T. Glycoprotein V exerts local control of fibrin. Nat Cardiovasc Res 2, 335–336 (2023).

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