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Hemogenic activity of lymphatic endothelium unleashed

Specialized endothelial cells within certain embryonic blood vessels can generate hematopoietic cells. A recent study reveals blood-forming capacity also within embryonic lymphatic endothelium, which is suppressed during normal development by the lymphatic endothelial fate-determining transcription factor PROX1.

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Fig. 1: Schematic illustration of the blood-forming capacity of endothelial cells in the mouse embryo.


  1. Emmel, V. Am. J. Anat. 19, 401–421 (1916).

    Article  Google Scholar 

  2. Jordan, H. Anat. Rec. 10, 417–420 (1916).

    Article  Google Scholar 

  3. Wu, Y. & Hirschi, K. K. Annu. Rev. Physiol. 83, 17–37 (2021).

    Article  CAS  PubMed  Google Scholar 

  4. Escobedo, N. & Oliver, G. Annu. Rev. Cell Dev. Biol. 32, 677–691 (2016).

    Article  CAS  PubMed  Google Scholar 

  5. Jafree, D. J., Long, D. A., Scambler, P. J. & Ruhrberg, C. Angiogenesis 24, 271–288 (2021).

    Article  PubMed  PubMed Central  Google Scholar 

  6. Stanczuk, L. et al. Cell Rep. 10, 1708–1721 (2015).

    Article  CAS  PubMed  Google Scholar 

  7. Chen, C.-Y. et al. J. Clin. Invest. 122, 2006–2017 (2012).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  8. Chen, J. et al. Dev. Cell 56, 3115–3127 (2021).

    Article  CAS  PubMed  Google Scholar 

  9. Das, R. N. et al. Nature 606, 570–575 (2022).

    Article  CAS  PubMed  Google Scholar 

  10. Kazenwadel, J. et al. Nature (2023).

    Article  PubMed  Google Scholar 

  11. Brouillard, P. et al. Nat. Rev. Dis. Primer 7, 77 (2021).

    Article  Google Scholar 

  12. Grimm, L. et al. Preprint at biorXiv (2022).

Download references

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Correspondence to Taija Mäkinen.

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Mäkinen, T. Hemogenic activity of lymphatic endothelium unleashed. Nat Cardiovasc Res 2, 230–231 (2023).

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