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Hemogenic activity of lymphatic endothelium unleashed

Nature Cardiovascular Research volume 2, pages 230–231 (2023)Cite this article

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Specialized endothelial cells within certain embryonic blood vessels can generate hematopoietic cells. A recent study reveals blood-forming capacity also within embryonic lymphatic endothelium, which is suppressed during normal development by the lymphatic endothelial fate-determining transcription factor PROX1.

In a recent study published in Nature, Kazenwadel and colleagues10 report for the first time that lymphatic endothelium possesses the capacity to form hematopoietic offspring. The authors find that the hemogenic activity of the embryonic lymphatic endothelium is unleashed upon downregulation of the LEC fate-determining transcription factor PROX1 (Fig. 1b), which suggests that during normal vascular development, PROX1 suppresses hematopoietic fate of LECs.

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Fig. 1: Schematic illustration of the blood-forming capacity of endothelial cells in the mouse embryo.

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  1. Uppsala University, Department of Immunology, Genetics and Pathology, Uppsala, Sweden

    Taija Mäkinen

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  1. Taija Mäkinen
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Correspondence to Taija Mäkinen.

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The author declares no competing interests.

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Mäkinen, T. Hemogenic activity of lymphatic endothelium unleashed. Nat Cardiovasc Res 2, 230–231 (2023). https://doi.org/10.1038/s44161-023-00231-z

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