Specialized endothelial cells within certain embryonic blood vessels can generate hematopoietic cells. A recent study reveals blood-forming capacity also within embryonic lymphatic endothelium, which is suppressed during normal development by the lymphatic endothelial fate-determining transcription factor PROX1.
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Mäkinen, T. Hemogenic activity of lymphatic endothelium unleashed. Nat Cardiovasc Res 2, 230–231 (2023). https://doi.org/10.1038/s44161-023-00231-z