Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • News & Views
  • Published:

Epigenetics

KDM8 prevents heart failure by controlling cardiac metabolism

Nature Cardiovascular Research volume 2, pages 106–107 (2023)Cite this article

Subjects

The mechanisms that link altered metabolism and heart failure remain unclear. A new study defines the role of the lysine demethylase KDM8 in preventing the initiation of dilated cardiomyopathy through epigenetic control of homeostatic cardiac metabolism.

This is a preview of subscription content, access via your institution

Access options

Buy this article

  • Purchase on SpringerLink
  • Instant access to full article PDF
Buy now

Prices may be subject to local taxes which are calculated during checkout

References

  1. Yu, J., Zeng, C. & Wang, Y. Curr. Opin. Cardiol. 34, 260–269 (2019).

    Article  PubMed  PubMed Central  Google Scholar 

  2. Berry, J. M., Cao, D. J., Rothermel, B. A. & Hill, J. A. Expert Opin. Drug Saf. 7, 53–67 (2008).

    Article  CAS  PubMed  Google Scholar 

  3. Papait, R., Serio, S. & Condorelli, G. Physiol. Rev. 100, 1753–1777 (2020).

    Article  CAS  PubMed  Google Scholar 

  4. Hyun, K., Jeon, J., Park, K. & Kim, J. Exp. Mol. Med. 49, e324 (2017).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  5. Hsia, D. A. et al. Proc. Natl Acad. Sci. USA 107, 9671–9676 (2010).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  6. Wang, H. J. et al. Oncogene 38, 17–32 (2019).

    Article  CAS  PubMed  Google Scholar 

  7. Ahmed, A. et al. Nat. Cardiovasc. Res. https://doi.org/10.1038/s44161-023-00214-0 (2023).

    Article  Google Scholar 

  8. Keating, S. T. & El-Osta, A. Circ. Res. 116, 715–736 (2015).

    Article  CAS  PubMed  Google Scholar 

  9. Yu, J. R. et al. Sci. Adv. 7, eabg7444 (2021).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  10. Pepin, M. E. et al. Lab. Invest. 99, 371–386 (2019).

    Article  CAS  PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Department of Pathology, Division of Molecular and Cellular Pathology, University of Alabama at Birmingham, Birmingham, AL, USA

    Sayan Bakshi & Adam R. Wende

Authors
  1. Sayan Bakshi
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Adam R. Wende
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Adam R. Wende.

Ethics declarations

Competing interests

The authors declare no competing interests.

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Bakshi, S., Wende, A.R. KDM8 prevents heart failure by controlling cardiac metabolism. Nat Cardiovasc Res 2, 106–107 (2023). https://doi.org/10.1038/s44161-023-00229-7

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1038/s44161-023-00229-7

Search

Advanced search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing