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Epigenetics

KDM8 prevents heart failure by controlling cardiac metabolism

The mechanisms that link altered metabolism and heart failure remain unclear. A new study defines the role of the lysine demethylase KDM8 in preventing the initiation of dilated cardiomyopathy through epigenetic control of homeostatic cardiac metabolism.

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References

  1. Yu, J., Zeng, C. & Wang, Y. Curr. Opin. Cardiol. 34, 260–269 (2019).

    Article  PubMed  PubMed Central  Google Scholar 

  2. Berry, J. M., Cao, D. J., Rothermel, B. A. & Hill, J. A. Expert Opin. Drug Saf. 7, 53–67 (2008).

    Article  CAS  PubMed  Google Scholar 

  3. Papait, R., Serio, S. & Condorelli, G. Physiol. Rev. 100, 1753–1777 (2020).

    Article  CAS  PubMed  Google Scholar 

  4. Hyun, K., Jeon, J., Park, K. & Kim, J. Exp. Mol. Med. 49, e324 (2017).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  5. Hsia, D. A. et al. Proc. Natl Acad. Sci. USA 107, 9671–9676 (2010).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  6. Wang, H. J. et al. Oncogene 38, 17–32 (2019).

    Article  CAS  PubMed  Google Scholar 

  7. Ahmed, A. et al. Nat. Cardiovasc. Res. https://doi.org/10.1038/s44161-023-00214-0 (2023).

    Article  Google Scholar 

  8. Keating, S. T. & El-Osta, A. Circ. Res. 116, 715–736 (2015).

    Article  CAS  PubMed  Google Scholar 

  9. Yu, J. R. et al. Sci. Adv. 7, eabg7444 (2021).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  10. Pepin, M. E. et al. Lab. Invest. 99, 371–386 (2019).

    Article  CAS  PubMed  Google Scholar 

Download references

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Correspondence to Adam R. Wende.

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Bakshi, S., Wende, A.R. KDM8 prevents heart failure by controlling cardiac metabolism. Nat Cardiovasc Res 2, 106–107 (2023). https://doi.org/10.1038/s44161-023-00229-7

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