Clonal hematopoiesis of indeterminate potential (CHIP) is a blood disorder that can increase the risk of cardiovascular disease. A new study reveals that CHIP driven by somatic mutations in DNA damage repair genes increases the risk of CVD in humans, and provides mechanistic insights in murine models.
This is a preview of subscription content, access via your institution
Access options
Subscribe to this journal
Receive 12 digital issues and online access to articles
$119.00 per year
only $9.92 per issue
Buy this article
- Purchase on Springer Link
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
References
Challen, G. A. & Goodell, M. A. Blood 136, 1590–1598 (2020).
Young, A. L., Challen, G. A., Birmann, B. M. & Druley, T. E. Nat. Commun. 7, 12484 (2016).
Jaiswal, S. et al. N. Engl. J. Med. 377, 111–121 (2017).
Izzo, F. et al. Nat. Genet. 52, 378–387 (2020).
Zekavat, S. M. Nat. Cardiovasc. Res. https://doi.org/10.1038/s44161-022-00206-6 (2023).
Tall, A. R. & Fuster, J. J. Nat. Cardiovasc. Res. 1, 116–124 (2022).
Murphy, A. J. & Tall, A. R. Circ. Res. 114, 236–238 (2014).
Robbins, C. S. et al. Nat. Med. 19, 1166–1172 (2013).
Tacke, F. et al. J. Clin. Invest. 117, 185–194 (2007).
Sinha, S. K. et al. Arterioscler. Thromb. Vasc. Biol. 41, 220–233 (2021).
Guevara, N. V., Kim, H. S., Antonova, E. I. & Chan, L. Nat. Med. 5, 335–339 (1999).
van Vlijmen, B. J. et al. Circ. Res. 88, 780–786 (2001).
Author information
Authors and Affiliations
Corresponding author
Ethics declarations
Competing interests
The authors declare no competing interests.
Rights and permissions
About this article
Cite this article
Nagareddy, P.R., Murphy, A.J. TP53 clonal hematopoiesis promotes atherosclerosis. Nat Cardiovasc Res 2, 102–103 (2023). https://doi.org/10.1038/s44161-022-00212-8
Published:
Issue Date:
DOI: https://doi.org/10.1038/s44161-022-00212-8
