Clonal hematopoiesis of indeterminate potential (CHIP) is a blood disorder that can increase the risk of cardiovascular disease. A new study reveals that CHIP driven by somatic mutations in DNA damage repair genes increases the risk of CVD in humans, and provides mechanistic insights in murine models.
This is a preview of subscription content, access via your institution
Access Nature and 54 other Nature Portfolio journals
Get Nature+, our best-value online-access subscription
$29.99 per month
cancel any time
Subscribe to this journal
Receive 12 digital issues and online access to articles
$119.00 per year
only $9.92 per issue
Rent or buy this article
Get just this article for as long as you need it
Prices may be subject to local taxes which are calculated during checkout
Challen, G. A. & Goodell, M. A. Blood 136, 1590–1598 (2020).
Young, A. L., Challen, G. A., Birmann, B. M. & Druley, T. E. Nat. Commun. 7, 12484 (2016).
Jaiswal, S. et al. N. Engl. J. Med. 377, 111–121 (2017).
Izzo, F. et al. Nat. Genet. 52, 378–387 (2020).
Zekavat, S. M. Nat. Cardiovasc. Res. https://doi.org/10.1038/s44161-022-00206-6 (2023).
Tall, A. R. & Fuster, J. J. Nat. Cardiovasc. Res. 1, 116–124 (2022).
Murphy, A. J. & Tall, A. R. Circ. Res. 114, 236–238 (2014).
Robbins, C. S. et al. Nat. Med. 19, 1166–1172 (2013).
Tacke, F. et al. J. Clin. Invest. 117, 185–194 (2007).
Sinha, S. K. et al. Arterioscler. Thromb. Vasc. Biol. 41, 220–233 (2021).
Guevara, N. V., Kim, H. S., Antonova, E. I. & Chan, L. Nat. Med. 5, 335–339 (1999).
van Vlijmen, B. J. et al. Circ. Res. 88, 780–786 (2001).
The authors declare no competing interests.
Rights and permissions
About this article
Cite this article
Nagareddy, P.R., Murphy, A.J. TP53 clonal hematopoiesis promotes atherosclerosis. Nat Cardiovasc Res 2, 102–103 (2023). https://doi.org/10.1038/s44161-022-00212-8