Regulatory elements including promoters and enhancers control tissue- and context-dependent gene expression. A new study presents an atlas of transcribed regulatory elements in human heart compartments, and their changes in transcription in the failing heart.
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Christoffels, V.M., Barnett, P. Regulatory element usage in healthy and failing human heart tissue. Nat Cardiovasc Res 2, 10–12 (2023). https://doi.org/10.1038/s44161-022-00192-9