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Transcriptional regulation

Regulatory element usage in healthy and failing human heart tissue

Regulatory elements including promoters and enhancers control tissue- and context-dependent gene expression. A new study presents an atlas of transcribed regulatory elements in human heart compartments, and their changes in transcription in the failing heart.

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Fig. 1: State- and genetic variant-dependent transcription of enhancers, a class of regulatory elements in the genome.


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Correspondence to Vincent M. Christoffels or Phil Barnett.

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The authors declare no competing financial interests.

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Christoffels, V.M., Barnett, P. Regulatory element usage in healthy and failing human heart tissue. Nat Cardiovasc Res 2, 10–12 (2023).

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