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Chasing youth on the outside: unique features of the human fetal epicardium

The epicardium has an active role in the formation of fetal and neonatal mammalian hearts, which retain the ability to regenerate. A single-cell comparison of human fetal and adult epicardial cells defines the transcriptomic programs that are specific to the fetal epicardium that could be harnessed to repair the injured adult heart.

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Fig. 1: Activity of the human epicardium.


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Correspondence to Anke M. Smits or Marie Jose Goumans.

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Smits, A.M., Goumans, M.J. Chasing youth on the outside: unique features of the human fetal epicardium. Nat Cardiovasc Res 1, 1130–1131 (2022).

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