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Sleep and atherosclerosis

Sleep calibrates atherosclerotic cardiovascular disease

Nature Cardiovascular Research volume 1, pages 1104–1106 (2022)Cite this article

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Sleep modulates cardiovascular health, and recent studies have begun to uncover underlying mechanistic links. An integrated translational approach that combines animal models and human trials will enrich scientific discovery, improve therapy, and help to alleviate the global burden of insufficient sleep and cardiovascular disease.

Atherosclerotic cardiovascular disease (ASCVD) and its associated consequences — myocardial infarction, stroke and peripheral artery disease — remain major contributors to mortality worldwide. Over the past few decades, new therapeutic treatments have emerged that control hypercholesterolemia, hypertension and diabetes, while public health initiatives have substantially decreased smoking and continue to address obesity. Despite these achievements, the rates of ASCVD continue to rise. Moreover, global success at combating communicable diseases has extended lifespan and expanded the pool of people at risk for ASCVD to include populations in developing countries that often live in bright, noisy and overcrowded cities. Together, these factors have contributed to a persistent residual ASCVD risk that remains high.

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Fig. 1: Sleep and cardiovascular health.

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Acknowledgements

This work was supported by National Institutes of Health (NIH) grants R00HL151750 and R01HL158534, and the Cure Alzheimer’s Fund (to C.S.M.).

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Authors and Affiliations

  1. Division of Pulmonary, Critical Care and Sleep Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, USA

    Oren Cohen & Neomi A. Shah

  2. Cardiovascular Research Institute and the Department of Medicine, Cardiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA

    Cameron S. McAlpine

  3. Nash Family Department of Neuroscience, Icahn School of Medicine at Mount Sinai, New York, NY, USA

    Cameron S. McAlpine

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  1. Oren Cohen
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  2. Neomi A. Shah
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  3. Cameron S. McAlpine
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Correspondence to Cameron S. McAlpine.

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Cohen, O., Shah, N.A. & McAlpine, C.S. Sleep calibrates atherosclerotic cardiovascular disease. Nat Cardiovasc Res 1, 1104–1106 (2022). https://doi.org/10.1038/s44161-022-00190-x

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