Skip to main content

Thank you for visiting You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

Sleep and atherosclerosis

Sleep calibrates atherosclerotic cardiovascular disease

Sleep modulates cardiovascular health, and recent studies have begun to uncover underlying mechanistic links. An integrated translational approach that combines animal models and human trials will enrich scientific discovery, improve therapy, and help to alleviate the global burden of insufficient sleep and cardiovascular disease.

This is a preview of subscription content, access via your institution

Access options

Rent or buy this article

Prices vary by article type



Prices may be subject to local taxes which are calculated during checkout

Fig. 1: Sleep and cardiovascular health.

Similar content being viewed by others


  1. Wang, C. et al. Eur. Heart J. 40, 1620–1629 (2019).

    Article  Google Scholar 

  2. Domínguez, F. et al. J. Am. Coll. Cardiol. 73, 134–144 (2019).

    Article  Google Scholar 

  3. Kundel, V. et al. J. Clin. Sleep Med. 17, 2009–2018 (2021).

    Article  Google Scholar 

  4. Daghlas, I. et al. J. Am. Coll. Cardiol. 74, 1304–1314 (2019).

    Article  CAS  Google Scholar 

  5. Goodman, M. O. et al. Circ. Genom. Precis. Med. 15, e003535 (2022).

    Article  CAS  Google Scholar 

  6. McAlpine, C. S. et al. Nature 566, 383–387 (2019).

    Article  CAS  Google Scholar 

  7. Heyde, A. et al. Cell 184, 1348–1361.e22 (2021).

    Article  CAS  Google Scholar 

  8. McAlpine, C. S. et al. J. Exp. Med. 219, e20220081 (2022).

    Article  CAS  Google Scholar 

  9. Vallat, R., Shah, V. D., Redline, S., Attia, P. & Walker, M. P. PLoS Biol. 18, 1–11 (2020).

    Article  Google Scholar 

  10. McEvoy, R. D. et al. N. Engl. J. Med. 375, 919–931 (2016).

    Article  Google Scholar 

  11. Nadeem, R. et al. J. Clin. Sleep Med. 9, 1003–1012 (2013).

    Article  Google Scholar 

  12. Vgontzas, A. N. et al. J. Clin. Endocrinol. Metab. 89, 4409–4413 (2004).

    Article  CAS  Google Scholar 

  13. Malhotra, A. et al. Sleep (Basel) 36, 573–582 (2013).

    Article  Google Scholar 

  14. Younes, M., Younes, M. & Giannouli, E. J. Clin. Sleep Med. 12, 735–746 (2016).

    Article  Google Scholar 

Download references


This work was supported by National Institutes of Health (NIH) grants R00HL151750 and R01HL158534, and the Cure Alzheimer’s Fund (to C.S.M.).

Author information

Authors and Affiliations


Corresponding author

Correspondence to Cameron S. McAlpine.

Ethics declarations

Competing interests

The authors declare no competing interests.

Rights and permissions

Reprints and Permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Cohen, O., Shah, N.A. & McAlpine, C.S. Sleep calibrates atherosclerotic cardiovascular disease. Nat Cardiovasc Res 1, 1104–1106 (2022).

Download citation

  • Published:

  • Issue Date:

  • DOI:


Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing