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Heart failure

IGFBP7 on the road to heart failure: driver or passenger?

Increasing evidence suggests that IGFBP7 may be an accurate biomarker for heart failure. A new study shows that beyond its diagnostic value, IGFBP7 may drive the detrimental effects of pressure overload in mice by a mechanism that, at least in part, involves the regulation of senescence by an IGF-1R–IR–FOXO3a signaling cascade.

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Fig. 1: IGFBP7 as a potential biomediator in heart failure.


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This work was supported by FONDAP grant 15130011 (J.R., S.L.) and FONDECYT 11181000 (J.R.) and 1200490 (S.L.).

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Correspondence to Sergio Lavandero.

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The authors declare no competing interests.

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Riquelme, J.A., Lavandero, S. IGFBP7 on the road to heart failure: driver or passenger?. Nat Cardiovasc Res 1, 1121–1123 (2022).

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