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Heart failure

IGFBP7 on the road to heart failure: driver or passenger?

Nature Cardiovascular Research volume 1, pages 1121–1123 (2022)Cite this article

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Increasing evidence suggests that IGFBP7 may be an accurate biomarker for heart failure. A new study shows that beyond its diagnostic value, IGFBP7 may drive the detrimental effects of pressure overload in mice by a mechanism that, at least in part, involves the regulation of senescence by an IGF-1R–IR–FOXO3a signaling cascade.

Heart failure is a highly prevalent clinical syndrome worldwide1. Evidence suggests that multimorbidity is prevalent in both heart failure with reduced ejection fraction (HFrEF) and heart failure with preserved ejection fraction (HFpEF), but it appears to be more severe in patients with HFpEF, and the risk of this form of heart failure increases markedly with age2. This phenomenon is of high clinical relevance because, although there currently are multiple pharmacological options to treat HFrEF, including beta-blockers, angiotensin II receptor type 1 antagonists and angiotensin-converting enzyme inhibitors, there are none for HFpEF, although the sodium/glucose transporter 2 inhibitors (SGLT2i)3,4 show promise. Therefore, it is of utmost importance to thoroughly understand the pathophysiology of HFpEF in order to identify new therapeutic targets that could effectively manage this disease.

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Fig. 1: IGFBP7 as a potential biomediator in heart failure.

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Acknowledgements

This work was supported by FONDAP grant 15130011 (J.R., S.L.) and FONDECYT 11181000 (J.R.) and 1200490 (S.L.).

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Authors and Affiliations

  1. Advanced Center for Chronic Diseases (ACCDiS), Facultad de Ciencias Químicas y Farmacéuticas & Facultad de Medicina, Universidad de Chile, Santiago, Chile

    Jaime A. Riquelme & Sergio Lavandero

  2. Interuniversity Center for Healthy Aging, Santiago, Chile

    Jaime A. Riquelme

  3. Cardiology Division, Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, TX, USA

    Sergio Lavandero

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  1. Jaime A. Riquelme
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  2. Sergio Lavandero
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Correspondence to Sergio Lavandero.

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Riquelme, J.A., Lavandero, S. IGFBP7 on the road to heart failure: driver or passenger?. Nat Cardiovasc Res 1, 1121–1123 (2022). https://doi.org/10.1038/s44161-022-00189-4

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