Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • News & Views
  • Published:

Atherosclerosis and platelets

Soluble guanylyl cyclase in platelets keeps atherosclerosis at bay

The contribution of platelets to atherothrombosis is well established. Accumulating genome-wide association studies have revealed several variants of genes encoding molecules along the nitric oxide (NO)–soluble guanylyl cyclase (sGC)–cyclic guanosine-3′,5′-monophosphate (cGMP) pathway that are associated with increased risk of coronary artery disease; however, the cell types and functional impact of these risk variants remain poorly understood. Mauersberger et al. now demonstrate that platelet-specific knockout of a transcript encoding sGC increased atherosclerosis, whereas pharmacological stimulators of sGC reduced lesions via a paracrine effect of angiopoietin-1 on endothelial cell–leukocyte interactions.

This is a preview of subscription content, access via your institution

Relevant articles

Open Access articles citing this article.

Access options

Buy this article

Prices may be subject to local taxes which are calculated during checkout

Fig. 1: Atheroprotective effects of the non-risk sGC allele.

References

  1. Mussbacher, M., Pirabe, A., Brunnthaler, L., Schrottmaier, W. C. & Assinger, A. Front. Physiol. 12, 678362 (2021).

    Article  Google Scholar 

  2. Lievens, D. & von Hundelshausen, P. Thromb. Haemost. 106, 827–838 (2011).

    Article  CAS  Google Scholar 

  3. Muhlestein, J. B. Thromb. Haemost. 103, 71–82 (2010).

    Article  CAS  Google Scholar 

  4. Massberg, S. et al. J. Exp. Med. 196, 887–896 (2002).

    Article  CAS  Google Scholar 

  5. Sim, J. Y. Korean J. Anesthesiol. 58, 4–14 (2010).

    Article  CAS  Google Scholar 

  6. Searles, C. D. Congest. Heart Fail. 8, 142–155 (2002).

    Article  CAS  Google Scholar 

  7. Consortium, C. A. D. et al. Nat. Genet. 45, 25–33 (2013).

    Article  Google Scholar 

  8. Wobst, J. et al. Basic Res. Cardiol. 111, 51 (2016).

    Article  Google Scholar 

  9. Mauersberger, C. et al. Nat. Cardiovasc. Res. https://doi.org/10.1038/s44161-022-00175-w (2022).

    Article  Google Scholar 

  10. Dangel, O. et al. J. Thromb. Haemost. 8, 1343–1352 (2010).

    Article  CAS  Google Scholar 

  11. Segura-Puimedon, M. et al. Am. J. Pathol. 186, 2220–2231 (2016).

    Article  CAS  Google Scholar 

  12. Tsou, C. Y. et al. Acta Physiol. 210, 799–810 (2014).

    Article  CAS  Google Scholar 

  13. Zhang, G. et al. Blood 118, 3670–3679 (2011).

    Article  CAS  Google Scholar 

  14. Kessler, T. et al. Circulation 136, 476–489 (2017).

    Article  CAS  Google Scholar 

Download references

Acknowledgements

Supported by the US National Institutes of Health (HL115141, HL134849, HL148207, HL148355, HL153356 to M.W.F.) and the American Heart Association (18SFRN33900144 and 20SFRN35200163 to M.W.F.).

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Mark W. Feinberg.

Ethics declarations

Competing interests

The authors declare no competing interests.

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Jamaiyar, A., Chen, J. & Feinberg, M.W. Soluble guanylyl cyclase in platelets keeps atherosclerosis at bay. Nat Cardiovasc Res 1, 1124–1126 (2022). https://doi.org/10.1038/s44161-022-00188-5

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1038/s44161-022-00188-5

This article is cited by

Search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing