The contribution of platelets to atherothrombosis is well established. Accumulating genome-wide association studies have revealed several variants of genes encoding molecules along the nitric oxide (NO)–soluble guanylyl cyclase (sGC)–cyclic guanosine-3′,5′-monophosphate (cGMP) pathway that are associated with increased risk of coronary artery disease; however, the cell types and functional impact of these risk variants remain poorly understood. Mauersberger et al. now demonstrate that platelet-specific knockout of a transcript encoding sGC increased atherosclerosis, whereas pharmacological stimulators of sGC reduced lesions via a paracrine effect of angiopoietin-1 on endothelial cell–leukocyte interactions.
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Mussbacher, M., Pirabe, A., Brunnthaler, L., Schrottmaier, W. C. & Assinger, A. Front. Physiol. 12, 678362 (2021).
Lievens, D. & von Hundelshausen, P. Thromb. Haemost. 106, 827–838 (2011).
Muhlestein, J. B. Thromb. Haemost. 103, 71–82 (2010).
Massberg, S. et al. J. Exp. Med. 196, 887–896 (2002).
Sim, J. Y. Korean J. Anesthesiol. 58, 4–14 (2010).
Searles, C. D. Congest. Heart Fail. 8, 142–155 (2002).
Consortium, C. A. D. et al. Nat. Genet. 45, 25–33 (2013).
Wobst, J. et al. Basic Res. Cardiol. 111, 51 (2016).
Mauersberger, C. et al. Nat. Cardiovasc. Res. https://doi.org/10.1038/s44161-022-00175-w (2022).
Dangel, O. et al. J. Thromb. Haemost. 8, 1343–1352 (2010).
Segura-Puimedon, M. et al. Am. J. Pathol. 186, 2220–2231 (2016).
Tsou, C. Y. et al. Acta Physiol. 210, 799–810 (2014).
Zhang, G. et al. Blood 118, 3670–3679 (2011).
Kessler, T. et al. Circulation 136, 476–489 (2017).
Supported by the US National Institutes of Health (HL115141, HL134849, HL148207, HL148355, HL153356 to M.W.F.) and the American Heart Association (18SFRN33900144 and 20SFRN35200163 to M.W.F.).
The authors declare no competing interests.
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Jamaiyar, A., Chen, J. & Feinberg, M.W. Soluble guanylyl cyclase in platelets keeps atherosclerosis at bay. Nat Cardiovasc Res 1, 1124–1126 (2022). https://doi.org/10.1038/s44161-022-00188-5