Regulation of endothelial barrier function is critical to physiological function of the vasculature, which must dynamically change in many physiologic and pathologic settings. A new study emphasizes the complex relationship between VE-cadherin phosphorylation and vascular leak and the critical role of the tyrosine kinase Yes in this process.
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Supported in part by NIH grants HL062289 and HL149343 to M.S.
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Simons, M., Toomre, D. YES to junctions, no to Src. Nat Cardiovasc Res 1, 1116–1118 (2022). https://doi.org/10.1038/s44161-022-00185-8
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DOI: https://doi.org/10.1038/s44161-022-00185-8
