Skip to main content

Thank you for visiting You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

Endothelial permeability

YES to junctions, no to Src

Regulation of endothelial barrier function is critical to physiological function of the vasculature, which must dynamically change in many physiologic and pathologic settings. A new study emphasizes the complex relationship between VE-cadherin phosphorylation and vascular leak and the critical role of the tyrosine kinase Yes in this process.

This is a preview of subscription content, access via your institution

Access options

Rent or buy this article

Get just this article for as long as you need it


Prices may be subject to local taxes which are calculated during checkout

Fig. 1: VEGFA activation of vascular permeability.


  1. Lampugnani, M. G., Dejana, E. & Giampietro, C. Cold Spring Harb. Perspect. Biol. (2018).

    Article  Google Scholar 

  2. Smith, R. O. et al. Elife (2020).

    Article  Google Scholar 

  3. Wessel, F. et al. Nat. Immunol. 15, 223–230 (2014).

    Article  CAS  Google Scholar 

  4. Schimmel, L. et al. Development (2020).

    Article  Google Scholar 

  5. Jin, Y. et al. Nat. Cardiovasc. Res. (2022).

    Article  Google Scholar 

  6. Levental, I., Lingwood, D., Grzybek, M., Coskun, Ü. & Simons, K. Proc. Natl Acad. Sci. USA 107, 22050–22054 (2010).

    Article  CAS  Google Scholar 

  7. Simons, M., Gordon, E. & Claesson-Welsh, L. Nat. Rev. Mol. Cell Biol. 17, 611–625 (2016).

    Article  CAS  Google Scholar 

  8. Sun, Z. et al. J. Exp. Med. 209, 1363–1377 (2012).

    Article  CAS  Google Scholar 

  9. Ninchoji, T. et al. Elife (2021).

    Article  Google Scholar 

  10. Li, X. et al. Front. Physiol. 11, 763 (2020).

    Article  Google Scholar 

  11. Corti, F. et al. Nat. Cardiovasc. Res. 1, 518–528 (2022).

    Article  CAS  Google Scholar 

  12. Whiteford, J. R. et al. Mol. Biol. Cell 22, 3609–3624 (2011).

    Article  CAS  Google Scholar 

  13. Plein, A., Fantin, A. & Ruhrberg, C. Microcirculation 21, 315–323 (2014).

    Article  CAS  Google Scholar 

  14. Roth, L. et al. Sci. Signal. 9, ra42 (2016).

    Article  Google Scholar 

  15. Fantin, A. et al. J. Exp. Med. 214, 1049–1064 (2017).

    Article  CAS  Google Scholar 

Download references


Supported in part by NIH grants HL062289 and HL149343 to M.S.

Author information

Authors and Affiliations


Corresponding author

Correspondence to Michael Simons.

Ethics declarations

Competing interests

The authors declare no competing interests.

Rights and permissions

Reprints and Permissions

About this article

Verify currency and authenticity via CrossMark

Cite this article

Simons, M., Toomre, D. YES to junctions, no to Src. Nat Cardiovasc Res 1, 1116–1118 (2022).

Download citation

  • Published:

  • Issue Date:

  • DOI:


Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing