Regulation of endothelial barrier function is critical to physiological function of the vasculature, which must dynamically change in many physiologic and pathologic settings. A new study emphasizes the complex relationship between VE-cadherin phosphorylation and vascular leak and the critical role of the tyrosine kinase Yes in this process.
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References
Lampugnani, M. G., Dejana, E. & Giampietro, C. Cold Spring Harb. Perspect. Biol. https://doi.org/10.1101/cshperspect.a029322 (2018).
Smith, R. O. et al. Elife https://doi.org/10.7554/eLife.54056 (2020).
Wessel, F. et al. Nat. Immunol. 15, 223–230 (2014).
Schimmel, L. et al. Development https://doi.org/10.1242/dev.185405 (2020).
Jin, Y. et al. Nat. Cardiovasc. Res. https://doi.org/10.1038/s44161-022-00172-z (2022).
Levental, I., Lingwood, D., Grzybek, M., Coskun, Ü. & Simons, K. Proc. Natl Acad. Sci. USA 107, 22050–22054 (2010).
Simons, M., Gordon, E. & Claesson-Welsh, L. Nat. Rev. Mol. Cell Biol. 17, 611–625 (2016).
Sun, Z. et al. J. Exp. Med. 209, 1363–1377 (2012).
Ninchoji, T. et al. Elife https://doi.org/10.7554/eLife.64944 (2021).
Li, X. et al. Front. Physiol. 11, 763 (2020).
Corti, F. et al. Nat. Cardiovasc. Res. 1, 518–528 (2022).
Whiteford, J. R. et al. Mol. Biol. Cell 22, 3609–3624 (2011).
Plein, A., Fantin, A. & Ruhrberg, C. Microcirculation 21, 315–323 (2014).
Roth, L. et al. Sci. Signal. 9, ra42 (2016).
Fantin, A. et al. J. Exp. Med. 214, 1049–1064 (2017).
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Supported in part by NIH grants HL062289 and HL149343 to M.S.
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Simons, M., Toomre, D. YES to junctions, no to Src. Nat Cardiovasc Res 1, 1116–1118 (2022). https://doi.org/10.1038/s44161-022-00185-8
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DOI: https://doi.org/10.1038/s44161-022-00185-8
