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Parenchymal border macrophages

An unnoticed player overseeing CSF flux

A new study shows that brain-resident parenchymal border macrophages (PBMs) maintain perivascular extracellular matrix composition by the release of matrix metalloproteinases. Depletion of PBMs suppressed glymphatic fluid transport, underscoring their responsibility for perivascular space homeostasis and brain protein clearance.

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Fig. 1: Functions and subtypes of parenchymal border macrophages (PBMs).


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We thank D. Xue for expert graphical support. This project has received funding from the Simons Foundation, the Dr. Miriam and Sheldon G. Adelson Medical Research Foundation, the US NIH/NINDS/NCCIH (R01AT012312, R01AT011439 and U19 NS128613) and the Novo Nordisk and Lundbeck Foundations, as well as the US Army Research Office (grant MURI W911NF1910280).

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Correspondence to Virginia Plá.

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Plá, V., Nedergaard, M. An unnoticed player overseeing CSF flux. Nat Cardiovasc Res 1, 1114–1115 (2022).

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