Skip to main content

Thank you for visiting You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

Categorizing atherosclerotic plaques by gene expression

Clustering the atherosclerotic plaques of patients based on gene expression unearths novel and clinically relevant heterogeneity beyond the established dogma of ‘stable’ and ‘unstable’ plaques.

This is a preview of subscription content, access via your institution

Access options

Rent or buy this article

Get just this article for as long as you need it


Prices may be subject to local taxes which are calculated during checkout

Fig. 1: Unsupervised clustering of plaques based on transcriptomics data.


  1. Pasterkamp, G., den Ruijter, H. M. & Giannarelli, C. False utopia of one unifying description of the vulnerable atherosclerotic plaque: a call for recalibration that appreciates the diversity of mechanisms leading to atherosclerotic disease. Arterioscler. Thromb. Vasc. Biol. 42, e86–e95 (2022). A Review that presents the diversity of mechanisms in atherosclerosis.

    Article  CAS  Google Scholar 

  2. Guinney, J. et al. The consensus molecular subtypes of colorectal cancer. Nat. Med. 21, 1350–1356 (2015). This paper reports colorectal cancer types based on transcriptome data.

    Article  CAS  Google Scholar 

  3. Pasterkamp, G. et al. Human validation of genes associated with a murine atherosclerotic phenotype. Arterioscler. Thromb. Vasc. Biol. 36, 1240–1246 (2016). This paper challenges the validity and interpretation of mouse models for atherosclerosis.

    Article  CAS  Google Scholar 

  4. Hartman, R. J. G. et al. Sex-stratified gene regulatory networks reveal female key driver genes of atherosclerosis involved in smooth muscle cell phenotype switching. Circulation 143, 713–726 (2021). This paper shows the importance of having well-balanced (in this case between males and females) cohorts in transcriptome studies.

    Article  CAS  Google Scholar 

  5. Depuydt, M. A. C. et al. Microanatomy of the human atherosclerotic plaque by single-cell transcriptomics. Circ. Res. 127, 1437–1455 (2020). This paper reports the cell-type repertoire of human atherosclerotic plaques.

    Article  CAS  Google Scholar 

Download references

Additional information

Publisher’s note Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.

This is a summary of: Mokry, M. et al. Transcriptomic-based clustering of human atherosclerotic plaques identifies subgroups with different underlying biology and clinical presentation. Nat. Cardiovasc. Res. (2022).

Rights and permissions

Reprints and Permissions

About this article

Verify currency and authenticity via CrossMark

Cite this article

Categorizing atherosclerotic plaques by gene expression. Nat Cardiovasc Res 1, 1134–1135 (2022).

Download citation

  • Published:

  • Issue Date:

  • DOI:


Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing