Clustering the atherosclerotic plaques of patients based on gene expression unearths novel and clinically relevant heterogeneity beyond the established dogma of ‘stable’ and ‘unstable’ plaques.
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Pasterkamp, G., den Ruijter, H. M. & Giannarelli, C. False utopia of one unifying description of the vulnerable atherosclerotic plaque: a call for recalibration that appreciates the diversity of mechanisms leading to atherosclerotic disease. Arterioscler. Thromb. Vasc. Biol. 42, e86–e95 (2022). A Review that presents the diversity of mechanisms in atherosclerosis.
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This is a summary of: Mokry, M. et al. Transcriptomic-based clustering of human atherosclerotic plaques identifies subgroups with different underlying biology and clinical presentation. Nat. Cardiovasc. Res. https://doi.org/10.1038/s44161-022-00171-0 (2022).
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Categorizing atherosclerotic plaques by gene expression. Nat Cardiovasc Res 1, 1134–1135 (2022). https://doi.org/10.1038/s44161-022-00174-x