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Channelosome and intracellular K+ channels in arrhythmia

Mutations in Kir2.1 resulting in defects in trafficking to the cardiomyocyte sarcolemma promote arrhythmia in Anderson–Tawil syndrome. Macias and colleagues provide a dual mechanism underlying cardiac arrhythmia that involves chaperoning of voltage-gated Na+ channels and a unique population of intracellular Kir2.1 channels that regulate Ca2+ cycling at the sarcoplasmic reticulum.

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Fig. 1: Dual mechanisms of cardiac arrhythmia in the Kir2.1∆314–315 model of Anderson–Tawil syndrome.


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Correspondence to Irena Levitan.

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Fancher, I., Levitan, I. Channelosome and intracellular K+ channels in arrhythmia. Nat Cardiovasc Res 1, 874–875 (2022).

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