Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • News & Views
  • Published:

Hematopoiesis

Fetal liver hematopoiesis revisited: a precast hierarchy

Nature Cardiovascular Research volume 1, pages 872–873 (2022)Cite this article

Subjects

Late fetal liver hematopoiesis was thought to primarily rely on hematopoietic stem cells (HSCs). Using new genetic-tracing tools, a study shows that EVI1-positive HSCs mainly undergo expansion in the fetal liver, while differentiated blood cell production depends on HSC-independent intermediate hematopoietic progenitors.

This is a preview of subscription content, access via your institution

Access options

Buy this article

  • Purchase on Springer Link
  • Instant access to full article PDF
Buy now

Prices may be subject to local taxes which are calculated during checkout

Fig. 1: Schematic of fetal hematopoietic system generation and maintenance.

References

  1. Vink, C. S., Mariani, S. A. & Dzierzak, E. HemaSphere 6, e737 (2022).

    Article  CAS  Google Scholar 

  2. Lewis, K., Yoshimoto, M. & Takebe, T. Stem Cell Res. Ther. 12, 139 (2021).

    Article  Google Scholar 

  3. Gao, X., Xu, C., Asada, N. & Frenette, P. S. Development 145, dev139691 (2018).

    Article  Google Scholar 

  4. Notta, F. et al. Science 351, aab2116 (2016).

    Article  Google Scholar 

  5. Gomez Perdiguero, E. et al. Nature 518, 547–551 (2015).

    Article  Google Scholar 

  6. Chen, M. J. et al. Cell Stem Cell 9, 541–552 (2011).

    Article  CAS  Google Scholar 

  7. Ulloa, B. A. et al. Cell Rep. 36, 109703 (2021).

    Article  CAS  Google Scholar 

  8. Patel, S. H. et al. Nature 606, 747–753 (2022).

    Article  CAS  Google Scholar 

  9. Soares-da-Silva, F. et al. J. Exp. Med. 218, e20201729 (2021).

    Article  CAS  Google Scholar 

  10. Yokomizo, T. et al. Nature https://doi.org/10.1038/s41586-022-05203-0 (2022).

  11. Dignum, T. et al. Cell Rep. 36, 109675 (2021).

    Article  CAS  Google Scholar 

  12. Barone, C., Orsenigo, R., Meneveri, R., Brunelli, S. & Azzoni, E. Cells 11, 1061 (2022).

    Article  CAS  Google Scholar 

  13. Rodriguez-Fraticelli, A. E. et al. Nature 553, 212–216 (2018).

    Article  CAS  Google Scholar 

  14. Busch, K. et al. Nature 518, 542–546 (2015).

    Article  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. School of Medicine and Surgery, University of Milano-Bicocca, Monza, Italy

    Emanuele Azzoni

  2. University of Milan, Department of Biosciences, Milan, Italy

    Alessandro Fantin

Authors
  1. Emanuele Azzoni
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Alessandro Fantin
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding authors

Correspondence to Emanuele Azzoni or Alessandro Fantin.

Ethics declarations

Competing interests

The authors declare no competing interests.

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Azzoni, E., Fantin, A. Fetal liver hematopoiesis revisited: a precast hierarchy. Nat Cardiovasc Res 1, 872–873 (2022). https://doi.org/10.1038/s44161-022-00142-5

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1038/s44161-022-00142-5

Search

Advanced search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing