Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

Interactions between aging and sex differences for cardiometabolic risk factors

We explored age-dependent patterns in sex differences for a wide range of cardiometabolic disease risk factors and observed widespread and divergent patterns for different risk-factor groups. These findings highlight the importance of taking both age and sex into account when assessing a person’s risk of developing cardiometabolic disease.

This is a preview of subscription content, access via your institution

Access options

Buy article

Get time limited or full article access on ReadCube.

$32.00

All prices are NET prices.

Fig. 1: The effect of aging on phenotype levels is different in men and women.

References

  1. EUGenMed Cardiovascular Clinical Study Group. Gender in cardiovascular diseases: impact on clinical manifestations, management, and outcomes. Eur. Heart J. 37, 24–34 (2016). A review article that provides an overview of sex differences in CMDs.

    Article  Google Scholar 

  2. Gerdts, E. & Regitz-Zagrosek, V. Sex differences in cardiometabolic disorders. Nat. Med. 25, 1657–1666 (2019). A review article that describes sex differences in CMD risk factors, disease incidence and underlying molecular pathways.

    Article  CAS  Google Scholar 

  3. Hägg, S. & Jylhävä, J. Sex differences in biological aging with a focus on human studies. eLife 10, e63425 (2021). A review article that presents known findings about underlying sex differences in aging.

    Article  Google Scholar 

  4. Scholtens, S. et al. Cohort Profile: LifeLines, a three-generation cohort study and biobank. Int. J. Epidemiol. 44, 1172–80 (2015). A paper that describes the population cohort used in our study.

    Article  Google Scholar 

Download references

Additional information

Publisher’s note Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.

This is a summary of: Zhernakova, D. V. et al. Age-dependent sex differences in cardiometabolic risk factors. Nat. Cardiovasc. Res. https://doi.org/10.1038/s44161-022-00131-8 (2022).

Rights and permissions

Reprints and Permissions

About this article

Verify currency and authenticity via CrossMark

Cite this article

Interactions between aging and sex differences for cardiometabolic risk factors. Nat Cardiovasc Res 1, 878–879 (2022). https://doi.org/10.1038/s44161-022-00136-3

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1038/s44161-022-00136-3

Search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing