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COMPARATIVE BIOLOGY

Human specificity encoded in the dark matter of the genome

Changes in gene regulatory networks leading to species-specific variations in cardiac structure and function remain to be fully investigated. A new study presents a repertoire of human-gained (absent in mice) cis-regulatory elements, some of which appear to be involved in the acquisition of human-specific cardiac features.

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Fig. 1: Discovery pipeline for human-specific cardiac enhancers.

References

  1. Davidson, E. H. & Erwin, D. H. Science 311, 796–797 (2006).

    Article  CAS  Google Scholar 

  2. Varshney, A. et al. in Systems Medicine Vol. 2 (ed. Wolkenhauer, O) 429–453 (Academic Press, 2021).

  3. Krishnan, A. et al. Pediatr. Res. 76, 500–507 (2014).

    Article  Google Scholar 

  4. Destici, E. et al. Nat. Cardiovasc. Res. https://doi.org/10.1038/s41591-022-01933-w (2022).

    Article  Google Scholar 

  5. Anderson, D. J. et al. Nat. Commun. 9, 1373 (2018).

    Article  Google Scholar 

  6. Paige, S. L. et al. Cell 151, 221–232 (2012).

    Article  CAS  Google Scholar 

  7. Wamstad, J. A. et al. Cell 151, 206–220 (2012).

    Article  CAS  Google Scholar 

  8. Bouveret, R. et al. Elife 4, e06942 (2015).

    Article  Google Scholar 

  9. Cannavò, E. et al. Curr. Biol. 26, 38–51 (2016).

    Article  Google Scholar 

  10. Osterwalder, M. et al. Nature 554, 239–243 (2018).

    Article  CAS  Google Scholar 

  11. Blow, M. J. et al. Nat. Genet. 42, 806–812 (2010).

    Article  CAS  Google Scholar 

  12. Chahal, G., Tyagi, S. & Ramialison, M. Differentiation 107, 11–23 (2019).

    Article  CAS  Google Scholar 

Download references

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Correspondence to Mirana Ramialison.

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Ramialison, M. Human specificity encoded in the dark matter of the genome. Nat Cardiovasc Res 1, 794–795 (2022). https://doi.org/10.1038/s44161-022-00129-2

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  • DOI: https://doi.org/10.1038/s44161-022-00129-2

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