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Human specificity encoded in the dark matter of the genome

Changes in gene regulatory networks leading to species-specific variations in cardiac structure and function remain to be fully investigated. A new study presents a repertoire of human-gained (absent in mice) cis-regulatory elements, some of which appear to be involved in the acquisition of human-specific cardiac features.

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Fig. 1: Discovery pipeline for human-specific cardiac enhancers.


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Correspondence to Mirana Ramialison.

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Ramialison, M. Human specificity encoded in the dark matter of the genome. Nat Cardiovasc Res 1, 794–795 (2022).

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