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COMPARATIVE BIOLOGY

Human specificity encoded in the dark matter of the genome

Nature Cardiovascular Research volume 1, pages 794–795 (2022)Cite this article

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Changes in gene regulatory networks leading to species-specific variations in cardiac structure and function remain to be fully investigated. A new study presents a repertoire of human-gained (absent in mice) cis-regulatory elements, some of which appear to be involved in the acquisition of human-specific cardiac features.

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Fig. 1: Discovery pipeline for human-specific cardiac enhancers.

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Authors and Affiliations

  1. Stem Cell Medicine, Murdoch Children’s Research Institute, Royal Children’s Hospital, Parkville, Victoria, Australia

    Mirana Ramialison

  2. The Novo Nordisk Foundation Center for Stem Cell Medicine (reNEW) Melbourne, Victoria, Australia

    Mirana Ramialison

  3. Australian Regenerative Medicine Institute and Systems Biology Institute Australia, Monash University, Clayton, Victoria, Australia

    Mirana Ramialison

  4. Department of Paediatrics, Royal Children’s Hospital, MDHS Faculty, The University of Melbourne, Melbourne, Victoria, Australia

    Mirana Ramialison

Authors
  1. Mirana Ramialison
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Correspondence to Mirana Ramialison.

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The author declares no competing interests.

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Ramialison, M. Human specificity encoded in the dark matter of the genome. Nat Cardiovasc Res 1, 794–795 (2022). https://doi.org/10.1038/s44161-022-00129-2

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