LTBP-2 expression is increased in the right ventricle and plasma of patients with pulmonary arterial hypertension. Circulating levels of LTBP-2 correlate with right ventricular function and predict long-term survival in two independent cohorts of patients with pulmonary arterial hypertension.
This is a preview of subscription content, access via your institution
Access options
Subscribe to this journal
Receive 12 digital issues and online access to articles
$119.00 per year
only $9.92 per issue
Buy this article
- Purchase on Springer Link
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
References
Lahm, T. et al. Assessment of right ventricular function in the research setting: knowledge gaps and pathways forward. an official american thoracic society research statement. Am. J. Respir. Crit. Care Med. 198, e15–e43 (2018). A Review article that provides the roadmap to further advance the state of knowledge in the field of RV failure.
Prisco, S. Z., Thenappan, T. & Prins, K. W. Treatment targets for right ventricular dysfunction in pulmonary arterial hypertension. JACC Basic Transl. Sci. 5, 1244–1260 (2020). A Review article that presents the mechanisms of right ventricular dysfunction in PAH and highlights potential targets for supporting RV function.
Rhodes, C. J. et al. Plasma proteome analysis in patients with pulmonary arterial hypertension: an observational cohort study. Lancet Resp. Med. 5, 717–726 (2017). A paper that reports a combination of nine circulating proteins identified in an unbiased screen that predicted the survival of patients with PAH.
Rhodes, C. J. et al. Using the plasma proteome for risk stratifying patients with pulmonary arterial hypertension. Am. J. Respir. Crit. Care. Med. 205, 1102–1111 (2022). A paper that presents the prognostic value of several circulating proteins in PAH that complement natriuretic peptide tests (NT-proBNP) and clinical risk scores.
Additional information
Publisher’s note Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.
This is a summary of: Boucherat, O. et al. Identification of LTBP-2 as a plasma biomarker for right ventricular dysfunction in human pulmonary arterial hypertension. Nat. Cardiovasc. Res. https://doi.org/10.1038/s44161-022-00113-w (2022).
Rights and permissions
About this article
Cite this article
From heart to blood: LTBP-2 is a promising biomarker for pulmonary arterial hypertension. Nat Cardiovasc Res 1, 804–805 (2022). https://doi.org/10.1038/s44161-022-00121-w
Published:
Issue Date:
DOI: https://doi.org/10.1038/s44161-022-00121-w
