LTBP-2 expression is increased in the right ventricle and plasma of patients with pulmonary arterial hypertension. Circulating levels of LTBP-2 correlate with right ventricular function and predict long-term survival in two independent cohorts of patients with pulmonary arterial hypertension.
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References
Lahm, T. et al. Assessment of right ventricular function in the research setting: knowledge gaps and pathways forward. an official american thoracic society research statement. Am. J. Respir. Crit. Care Med. 198, e15–e43 (2018). A Review article that provides the roadmap to further advance the state of knowledge in the field of RV failure.
Prisco, S. Z., Thenappan, T. & Prins, K. W. Treatment targets for right ventricular dysfunction in pulmonary arterial hypertension. JACC Basic Transl. Sci. 5, 1244–1260 (2020). A Review article that presents the mechanisms of right ventricular dysfunction in PAH and highlights potential targets for supporting RV function.
Rhodes, C. J. et al. Plasma proteome analysis in patients with pulmonary arterial hypertension: an observational cohort study. Lancet Resp. Med. 5, 717–726 (2017). A paper that reports a combination of nine circulating proteins identified in an unbiased screen that predicted the survival of patients with PAH.
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This is a summary of: Boucherat, O. et al. Identification of LTBP-2 as a plasma biomarker for right ventricular dysfunction in human pulmonary arterial hypertension. Nat. Cardiovasc. Res. https://doi.org/10.1038/s44161-022-00113-w (2022).
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From heart to blood: LTBP-2 is a promising biomarker for pulmonary arterial hypertension. Nat Cardiovasc Res 1, 804–805 (2022). https://doi.org/10.1038/s44161-022-00121-w
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DOI: https://doi.org/10.1038/s44161-022-00121-w