Heart failure is marked by metabolic insufficiency, but detailed understanding of the underlying metabolic rewiring has been limited. By applying state-of-the-art mass spectrometry to a large pool of human hearts in end-stage heart failure, we unveil numerous metabolic aberrations in human heart failure.
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References
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This is a summary of: Flam, E. et al. Integrated landscape of cardiac metabolism in end-stage human nonischemic dilated cardiomyopathy. Nat. Cardiovasc. Res. https://doi.org/10.1038/s44161-022-00117-6 (2022).
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Metabolic defects in failing human hearts. Nat Cardiovasc Res 1, 802–803 (2022). https://doi.org/10.1038/s44161-022-00120-x
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DOI: https://doi.org/10.1038/s44161-022-00120-x
