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IgE promotes pulmonary hypertension through mast cell–derived IL-6 and IL-13

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In lung tissues of pulmonary hypertension rodent models, B cell activation and immunoglobulin E (IgE) production lead to mast cell activation and release of the cytokines IL-6 and IL-13, which result in remodeling of vascular smooth muscle cells. Blockade of IgE with omalizumab, a clinically approved monoclonal antibody against IgE, alleviated the progression of experimental pulmonary hypertension.

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Fig. 1: Omalizumab ameliorates established PH in rats.

References

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This is a summary of: Shu, T. et al. Inhibition of immunoglobulin E attenuates pulmonary hypertension. Nat. Cardiovasc. Res. https://doi.org/10.1038/s44161-022-00095-9 (2022).

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IgE promotes pulmonary hypertension through mast cell–derived IL-6 and IL-13. Nat Cardiovasc Res 1, 609–610 (2022). https://doi.org/10.1038/s44161-022-00104-x

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