Transiently inducing proliferation of adult cardiomyocytes is a long-sought goal in the cardiac regeneration field. A new study shows that genetic deletion of calcineurin B1 and treatment with FK506 (tacrolimus, an FDA-approved inhibitor of calcineurin) induce cardiomyocyte proliferation in adult mice.
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Watanabe, H., Sucov, H.M. Cardiomyocyte proliferation by calcineurin inhibition. Nat Cardiovasc Res 1, 599–600 (2022). https://doi.org/10.1038/s44161-022-00100-1
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DOI: https://doi.org/10.1038/s44161-022-00100-1
