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Immune riders on the cardiac STORM

A mouse model of spontaneous arrhythmia in awake mice enables researchers to study how immune cells contribute to this process. The authors find opposing effects of the immune compartment, with neutrophils favoring arrhythmias by increasing oxidative stress and macrophages protecting against it via their phagocytic activity.

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Fig. 1: Different roles for immune cells in cardiac arrhythmia.


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Correspondence to Andrés Hidalgo.

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A.H. is a paid consultor for Flagship Pioneering for matters partly related to this article.

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Nicolás-Ávila, J.Á., Hidalgo, A. Immune riders on the cardiac STORM. Nat Cardiovasc Res 1, 603–604 (2022).

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