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Myosin modulators move forward with FDA approval of mavacamten

The US FDA recently approved mavacamten, a first-in-class myosin modulator, for obstructive hypertrophic cardiomyopathy. By targeting actin mechanobiology, myosin modulators are emerging as important medicines in cardiology.

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Fig. 1: Proposed mechanism of action for mavacamten.


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A.C.C. was supported by NIH Medical Scientist Training Program Training Grant T32GM007739 and an American Heart Association Predoctoral Fellowship.

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Correspondence to Alfred C. Chin or Sharlene M. Day.

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Competing interests

S.M.D. receives research funding from Bristol Myers Squibb, consults for Tenaya Therapeutics and Pfizer, and is on the data monitoring board for Cytokinetics. A.C.C. declares no competing interests.

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Chin, A.C., Day, S.M. Myosin modulators move forward with FDA approval of mavacamten. Nat Cardiovasc Res 1, 595–596 (2022).

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