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Myosin modulators move forward with FDA approval of mavacamten

Nature Cardiovascular Research volume 1, pages 595–596 (2022)Cite this article

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The US FDA recently approved mavacamten, a first-in-class myosin modulator, for obstructive hypertrophic cardiomyopathy. By targeting actin mechanobiology, myosin modulators are emerging as important medicines in cardiology.

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Fig. 1: Proposed mechanism of action for mavacamten.

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Acknowledgements

A.C.C. was supported by NIH Medical Scientist Training Program Training Grant T32GM007739 and an American Heart Association Predoctoral Fellowship.

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Authors and Affiliations

  1. Weill Cornell/Rockefeller/Sloan Kettering Tri-Institutional MD-PhD Program, New York, NY, USA

    Alfred C. Chin

  2. Center for Inherited Cardiovascular Disease, Division of Cardiovascular Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA

    Sharlene M. Day

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  1. Alfred C. Chin
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  2. Sharlene M. Day
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Corresponding authors

Correspondence to Alfred C. Chin or Sharlene M. Day.

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Competing interests

S.M.D. receives research funding from Bristol Myers Squibb, consults for Tenaya Therapeutics and Pfizer, and is on the data monitoring board for Cytokinetics. A.C.C. declares no competing interests.

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Chin, A.C., Day, S.M. Myosin modulators move forward with FDA approval of mavacamten. Nat Cardiovasc Res 1, 595–596 (2022). https://doi.org/10.1038/s44161-022-00093-x

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