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HEMATOPOIESIS

Modeling the temporal dynamics of clonal hematopoiesis

Clonal hematopoiesis is a risk factor for hematological cancers, cardiovascular diseases and death. Two papers now use new experimental and mathematical tools to quantify changes in the clonal composition of human blood over time, and the results have implications for the risk of cardiovascular diseases.

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Fig. 1: Somatic mutations in HSCs lead to a proliferative advantage and clonal expansion.

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Correspondence to Siddhartha Jaiswal.

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Competing interests

S.J. is a consultant to Novartis, Roche Genentech, AVRO Bio and Foresite Labs, and on the scientific advisory board for Bitterroot Bio. S.J. and A.G.B. are founders and equity holders of TenSixteen Bio.

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Jaiswal, S., Bick, A.G. Modeling the temporal dynamics of clonal hematopoiesis. Nat Cardiovasc Res 1, 537–538 (2022). https://doi.org/10.1038/s44161-022-00086-w

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