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VASCULAR REGENERATION

Lymphatic-to-blood vessel transdifferentiation in zebrafish

Blood vessels are thought to form either by de novo vasculogenesis or by angiogenesis from pre-existing blood vessels. Research now finds that anal fin blood vessels form by endothelial transdifferentiation from lymphatic vessels.

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Fig. 1: Simplified schematics showing how the views on the vasculature of ray-finned fishes have evolved.

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Correspondence to Kari Alitalo.

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Jeltsch, M., Alitalo, K. Lymphatic-to-blood vessel transdifferentiation in zebrafish. Nat Cardiovasc Res 1, 539–541 (2022). https://doi.org/10.1038/s44161-022-00073-1

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