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Lymphatic-to-blood vessel transdifferentiation in zebrafish

Blood vessels are thought to form either by de novo vasculogenesis or by angiogenesis from pre-existing blood vessels. Research now finds that anal fin blood vessels form by endothelial transdifferentiation from lymphatic vessels.

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Fig. 1: Simplified schematics showing how the views on the vasculature of ray-finned fishes have evolved.


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Correspondence to Kari Alitalo.

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Jeltsch, M., Alitalo, K. Lymphatic-to-blood vessel transdifferentiation in zebrafish. Nat Cardiovasc Res 1, 539–541 (2022).

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