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VASCULAR REGENERATION

Lymphatic-to-blood vessel transdifferentiation in zebrafish

Nature Cardiovascular Research volume 1, pages 539–541 (2022)Cite this article

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Blood vessels are thought to form either by de novo vasculogenesis or by angiogenesis from pre-existing blood vessels. Research now finds that anal fin blood vessels form by endothelial transdifferentiation from lymphatic vessels.

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Fig. 1: Simplified schematics showing how the views on the vasculature of ray-finned fishes have evolved.

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Authors and Affiliations

  1. Drug Research Program, University of Helsinki, Helsinki, Finland

    Michael Jeltsch

  2. Individualized Drug Therapy, University of Helsinki, Helsinki, Finland

    Michael Jeltsch

  3. Wihuri Research Institute, Helsinki, Finland

    Michael Jeltsch & Kari Alitalo

  4. Translational Cancer Medicine Research Program, Faculty of Medicine, University of Helsinki, Helsinki, Finland

    Kari Alitalo

  5. Helsinki University Hospital, Helsinki, Finland

    Kari Alitalo

Authors
  1. Michael Jeltsch
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  2. Kari Alitalo
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Correspondence to Kari Alitalo.

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The authors do not declare any conflict of interest.

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Jeltsch, M., Alitalo, K. Lymphatic-to-blood vessel transdifferentiation in zebrafish. Nat Cardiovasc Res 1, 539–541 (2022). https://doi.org/10.1038/s44161-022-00073-1

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