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Clinical utility of genomic analyses and polygenic risk scores for aortic diseases

Rupture or dissection of the aorta is often fatal. Tcheandjieu and colleagues now identify key pathways underlying aortic dilatation, a common prelude to acute aortic events, and assess the utility of a polygenic risk score to identify those at highest risk of aortic death in whom prophylactic surgical repair may be beneficial.

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  1. Renard, M. et al. J. Am. Coll. Cardiol. 72, 605–615 (2018).

    CAS  Article  Google Scholar 

  2. Tcheandjieu, C. et al. Nat. Genet. (2022).

    Article  PubMed  Google Scholar 

  3. Marziliano, N. et al. J. Investig. Genomics 5, 00072 (2018).

    Google Scholar 

  4. Klarin, D. et al. Circulation 142, 1633–1646 (2020).

    Article  Google Scholar 

  5. Portilla-Fernandez, E. et al. Hum. Mol. Genet. (2022).

    Article  PubMed  Google Scholar 

  6. Benjamins, J. W. et al. EBioMedicine 75, 103783 (2021).

    Article  Google Scholar 

  7. Celeng, C. et al. Eur. Radiol. 27, 2419–2425 (2017).

    Article  Google Scholar 

  8. van Andel, M. M. et al. Eur. Heart J. 41, 4181–4187 (2020).

    Article  Google Scholar 

  9. Golledge, J. et al. Trials 22, 962 (2021).

    CAS  Article  Google Scholar 

  10. Lawson, J. A. et al. J. Vasc. Soc. GB Irel. 1, 34–41 (2022).

    Google Scholar 

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Correspondence to Matthew J. Bown.

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Gellatly, C., Bown, M.J. Clinical utility of genomic analyses and polygenic risk scores for aortic diseases. Nat Cardiovasc Res 1, 542–543 (2022).

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