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AORTIC DISEASE

Clinical utility of genomic analyses and polygenic risk scores for aortic diseases

Rupture or dissection of the aorta is often fatal. Tcheandjieu and colleagues now identify key pathways underlying aortic dilatation, a common prelude to acute aortic events, and assess the utility of a polygenic risk score to identify those at highest risk of aortic death in whom prophylactic surgical repair may be beneficial.

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Correspondence to Matthew J. Bown.

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Gellatly, C., Bown, M.J. Clinical utility of genomic analyses and polygenic risk scores for aortic diseases. Nat Cardiovasc Res 1, 542–543 (2022). https://doi.org/10.1038/s44161-022-00058-0

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