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The quest to unravel the complex genomics of intracranial aneurysms

Nature Cardiovascular Research volume 1, pages 281–282 (2022)Cite this article

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After three decades of work, hypothesis-generating genomic approaches have led to the identification of several intracranial aneurysm risk loci and Mendelian mutations, involving several unexpected genes. These findings opened the door for exciting opportunities, unraveling the genomic architecture of brain aneurysms. The field is now ripe to face the next set of surprises in this long journey.

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Fig. 1: A putative model for the contribution of genetic, epigenetic and environmental factors in IA susceptibility.

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Acknowledgements

We thank K. Yasuno (Department of Neurosurgery, Yale University), K. Mishra-Gorur (Department of Neurosurgery, Yale University) and Mark Youngblood (Department of Neurosurgery, Northwestern University) for their input.

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  1. Department of Neurosurgery, Genetics and Neuroscience, Yale School of Medicine, New Haven, CT, USA

    Tanyeri Barak & Murat Günel

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  1. Tanyeri Barak
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  2. Murat Günel
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Correspondence to Murat Günel.

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The authors declare no competing interests.

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Barak, T., Günel, M. The quest to unravel the complex genomics of intracranial aneurysms. Nat Cardiovasc Res 1, 281–282 (2022). https://doi.org/10.1038/s44161-022-00051-7

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