Global or macrophage-specific knockout of Trpm2, which encodes the calcium-permeable ion channel TRPM2, protects mice against atherosclerosis induced by a high-fat diet. Mechanistically, activation of TRPM2 and the scavenger receptor CD36 promote the transformation of macrophages into inflammatory foam cells, thereby accelerating the development and progression of atherosclerosis.
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This is a summary of: Zong, P. et al. TRPM2 deficiency in mice protects against atherosclerosis by inhibiting TRPM2–CD36 inflammatory axis in macrophages. Nat. Cardiovas. Res. https://doi.org/10.1038/s44161-022-00027-7 (2022).
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Activation of macrophage TRPM2 and CD36 promotes atherosclerosis. Nat Cardiovasc Res 1, 294–295 (2022). https://doi.org/10.1038/s44161-022-00037-5