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ATHEROSCLEROSIS

New insights into cholesterol efflux via ABCA1

ABCA1 promotes the efflux of cholesterol from cells to HDL and has anti-atherogenic activities. Sun and Li present cryo-EM structures of ABCA1 in the ATP-free and ATP-bound states, which reveal bound cholesterol molecules and suggest a transmembrane cholesterol-transport mechanism.

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Fig. 1: ABCA1 in ATP-bound and ATP-free states.

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Correspondence to Alan R. Tall.

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Competing interests

A.T. is a scientific founder of 1016 Bio, and is on the scientific advisory board of Staten Biotechnologies and Beren Therapeutics.

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Tall, A.R., Wang, N. New insights into cholesterol efflux via ABCA1. Nat Cardiovasc Res 1, 198–199 (2022). https://doi.org/10.1038/s44161-022-00036-6

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