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Hydrogenation streamlines cyclolignan synthesis

Nature Synthesis volume 3, pages 937–938 (2024)Cite this article

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Enantioselective hydrogenation is a stalwart reaction in synthetic chemistry. Now, hydrogenation of tetrasubstituted 1,2-dihydronaphthalene esters gives access to more than 30 cyclolignan natural products.

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Fig. 1: Hydrogenation-enabled modular strategy for the synthesis of cyclolignan natural products.

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  1. Twitter: @SarlahLab

Authors and Affiliations

  1. Department of Chemistry, University of Illinois at Urbana−Champaign, Urbana, IL, USA

    David B. Ryffel & David Sarlah

  2. Carl R. Woese Institute for Genomic Biology, University of Illinois at Urbana–Champaign, Urbana, IL, USA

    David B. Ryffel & David Sarlah

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  1. David B. Ryffel
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  2. David Sarlah
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Correspondence to David Sarlah.

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The authors declare no competing interests.

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Ryffel, D.B., Sarlah, D. Hydrogenation streamlines cyclolignan synthesis. Nat. Synth 3, 937–938 (2024). https://doi.org/10.1038/s44160-024-00592-8

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