Owing to its structural complexity, the total synthesis of alchivemycin A has proved challenging. Now, the total synthesis of alchivemycin A is achieved using a chemoenzymatic approach that combines de novo skeleton construction with a late-stage enzymatic oxidation cascade. Following rational protein engineering of a key enzyme, the final product is obtained in high yield.
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References
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This is a summary of: Dong, H. et al. Chemoenzymatic total synthesis of alchivemycin A. Nat. Synth. https://doi.org/10.1038/s44160-024-00577-7 (2024).
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Total synthesis of alchivemycin A using a chemoenzymatic strategy. Nat. Synth 3, 1072–1073 (2024). https://doi.org/10.1038/s44160-024-00580-y
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DOI: https://doi.org/10.1038/s44160-024-00580-y
