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Protein modification

Horner–Wadsworth–Emmons olefination for bioconjugation

Nature Synthesis volume 3, pages 935–936 (2024)Cite this article

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Through site-specific generation of intermediary reactive aldehydes, Horner–Wadsworth–Emmons olefination can now deliver selective functionalization of stable recombinant proteins and monoclonal antibodies, whilst preserving protein integrity.

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Fig. 1: Site-specific HWE-olefination leveraging an intermediary enzyme-assisted in situ aldehyde generation.

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  1. Swiss Federal Institute of Technology Lausanne (EPFL), Lausanne, Switzerland

    Yimon Aye

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  1. Yimon Aye
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Correspondence to Yimon Aye.

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The author declares no competing interests.

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Aye, Y. Horner–Wadsworth–Emmons olefination for bioconjugation. Nat. Synth 3, 935–936 (2024). https://doi.org/10.1038/s44160-024-00571-z

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